Ovarian aging: mechanisms and intervention strategies

Abstract Ovarian reserve is essential for fertility and influences healthy aging in women. Advanced maternal age correlates with the progressive loss of both quantity quality oocytes. The molecular mechanisms various contributing factors underlying ovarian have been uncovered. In this review, we highlight some critical that impact oocyte during aging. Germ cell follicle at birth determines reproductive lifespan timing menopause female mammals. Accelerated diminishing leads to premature or insufficiency. Poor increasing could result from chromosomal cohesion deterioration misaligned chromosomes, telomere shortening, DNA damage associated genetic mutations, oxidative stress, mitochondrial dysfunction epigenetic alteration. We also discuss intervention strategies delay Both efficacy senotherapies by antioxidants against therapy are discussed. Functional oocytes ovarioids be rejuvenated pluripotent stem cells somatic cells. propose directions future interventions. As couples increasingly begin delaying parenthood life worldwide, understanding potential benefit women making earlier choices about their health.